The fall of the Parthian Empire was a process that was drawn out over more than two centuries. In its latter decades, it was weakened by dynastic struggles, which exacerbated problems both east and west in an empire that was largely decentralized. In the west, the Parthian problems were directly linked to the demise of the Seleucids, who the Parthians, ironically, helped eradicate in conjunction with Rome.
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http://warandgame.wordpress.com/2010/01/15/the-fall-of-the-parthian-empire/